By David Y. Hwang
50 reports each Neurologist may still Know offers key reports that form the present scientific perform of neurology. All neurologic subspecialties are coated, with a distinct emphasis on neurocritical care and vascular neurology. for every research, a concise precis is gifted with an emphasis at the effects and obstacles of the research, and its implications for perform. An illustrative medical case concludes each one evaluate, by means of short info on different suitable reports. this can be the 1st e-book of its variety to provide a suite of the main influential scientific trials in neurology which are specified sufficient for use on rounds, yet nonetheless simply digestible. it's a must-read for health and wellbeing care pros and an individual who desires to research extra in regards to the information at the back of scientific practice.
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Extra info for 50 Studies Every Neurologist Should Know (Fifty Studies Every Doctor Should Know)
Treatment with sumatriptan markedly improved ability to function normally: at 60 minutes, 45% could function normally compared with 9% treated with placebo; at 120 minutes, the numbers were 78% versus 22%. • Rescue medication was taken by 44% of those who received placebo alone, and 8%–12% of those assigned to any sumatriptan regimen. • Proportion of headache recurrence within 24 hours was 34%–38% in sumatriptan-treated patients versus 18% in placebo. • The most frequent adverse events in the sumatriptan group were injection site reaction, f lushing, and a feeling of heaviness.
Prior to this study, the 2006 guidelines from the International League Against Epilepsy (ILAE) listed only CBZ and phenytoin (PHT) as adequate comparators for adults with partial-onset seizures. 10 • The current 2013 ILAE recommendations for efficacious initial therapy for adults with partial-onset seizures, according to available trial data, are as follows:11 • Established (level A): LEV, ZNS, CBZ, PHT 30 E p i l eps y • Probably (level B): VPA • Possibly (level C): GBP, LTG, OXC, phenobarbital, TPM, vigabatrin • Potentially (level D): Clonazepam, primidone Summary and Implications: For patients with partial seizures, lamotrigine (LTG) had the lowest rate of treatment failure compared to all drugs (CBZ, TPM, GBP).
Treiman D et al. A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group. N Engl J Med. 1998;339(12):792–798. Lockey A. Emergency department drug therapy for status epilepticus in adults. Emerg Med J. 2002;19:96–100. 3. Brophy G, Bell R, Claassen J, Alldredge B, et al. Guidelines for the evaluation and management of status epilepticus. Neurocritcal Care. 2012;17(1):3–23. 4. Shaner DM, McCurdy SA, Herring MO, Gabor AJ.