Aging Mechanisms: Longevity, Metabolism, and Brain Aging by Nozomu Mori, Inhee Mook-Jung

By Nozomu Mori, Inhee Mook-Jung

This ebook brings jointly the main up to date info on fresh examine result of major laboratories on getting older technological know-how in East Asia, rather in Japan, Korea, and Hong Kong. beginning with a finished evaluation of assorted hypotheses on organic mechanisms of getting older through Dr. Sataro Goto, every one bankruptcy covers extensive features of the latest findings in aging-related themes: centenarian stories and genome research of progeria, metabolic biochemistry and neurobiology, sturdiness controls in yeast and nematodes, oxidative tension and calorie limit, and neurodegeneration mechanisms in Alzheimer’s and Huntington’s illnesses, with additional power healing ways to those age-related neurodegenerative illnesses. additionally integrated, partially, is a precis and the results of a systematic dialogue discussion board known as the Asian getting older middle for sturdiness (AACL) that has been held each year alternating among Japan and Korea over the past decade. This booklet can function an invaluable source for locating acceptable collaborators within the components it covers. the objective readership is made from graduate scholars and researchers at universities, clinical and/or life-science colleges, and biomedical and pharmaceutical institutes.

Why does getting older exist? How can we age? How is each one organism’s lifespan made up our minds? those are primary questions within the box. We should be nonetheless faraway from attaining a whole view of getting older mechanisms, yet this e-book, Aging Mechanisms, deals a very good chance to familiarize yourself with the main up to date growth within the biomedical learn of getting older in Japan and Korea, the 2 prime international locations for human longevity.

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This has now become one of the most widely accepted theories used to explain the mechanisms of aging. 9 Dysdifferentiation Theory of Aging • Epigenetic Theory of Aging Richard Cutler suggested that differentiated cells can undergo changes in transcription during aging, such that the strict pattern of gene expression is gradually relaxed, leading to the deterioration of the functions of cells and tissues (Cutler 1991). This idea, called the dysdifferentiation theory of aging, was based on the finding that the expression of globin or its related mRNA and murine leukemia virus RNA is increased in the brains and livers of aged mice compared to their younger counterparts (Ono and Cutler 1978).

Another frequently used method was to examine the heat-stability of an enzyme in cell or tissue extracts. An enzyme is likely to become heat-labile if it is altered such that the mixture of native and altered enzymes has a biphasic or quasi-biphasic heat-inactivation kinetic curves for the activity so that the percentage of the altered form of an enzyme could be evaluated (Houben et al. 1984). Thus, many altered proteins, mainly enzymes, have been reported to increase in cells and tissues with aging, suggesting that they may be responsible for the age-related decline of physiological functions.

J Gerontol A Biol Sci Med Sci 68:6–16 Subba Rao K, Martin GM, Loeb LA (1985) Fidelity of DNA polymerase-beta in neurons from young and very aged mice. J Neurochem 45:1273–1278 Szilard L (1959) On the nature of the aging process. Proc Natl Acad Sci U S A 45:30–45 Takahashi R, Goto S (1988) Fidelity of aminoacylation by rat-liver tyrosyl-tRNA synthetase. Effect of age. Eur J Biochem 178:381–386 Takahashi R, Goto S (1990) Alteration of aminoacyl-tRNA synthetase with age: heat-labilization of the enzyme by oxidative damage.

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