Amyotrophic Lateral Sclerosis by M. Maurer

By M. Maurer

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Dexpramipexole, the R(+) enantiomer of pramipexole, for the potential treatment of amyotrophic lateral sclerosis. IDrugs, Vol. 13, No. 12, pp. 911-920. V. C. (2010). Riluzole, neuroprotection and amyotrophic lateral sclerosis. Curr Med Chem, Vol. 17, No. 18, pp. 1942-1199. , Volanti, P. & Beghi, E. (2010). Lithium carbonate in amyotrophic lateral sclerosis: lack of efficacy in a dose-finding trial. Neurology, Vol. 75, No. 7, pp. 619-625. , Silani, V. & Ratti, A. (2011). RNA-binding proteins and RNA metabolism: a new scenario in the pathogenesis of Amyotrophic lateral sclerosis.

1974). , 1981). , 2005). 37 Insulin-like growth factor-1 (IGF-1) IGF-1 is a growth factor stimulated by the human growth hormone (hGH). It induces cell proliferation and differentiation (Rosenbloom, 2009). , 1998). , 2008). , 1986) did not show a benefit in ALS patients. , 2006). Currently, a phase I (NCT01041222) investigates the safety, tolerability, and activity familial ALS caused by SOD1 gene mutations. , 1971). 41 Lamotrigine Lamotrigine is an anti-epileptic drug with anti-excitotocicity effects.

2005). High dose vitamin E therapy in amyotrophic lateral sclerosis as add-on therapy to riluzole: results of a placebocontrolled double-blind study. J Neural Transm, Vol. 112, No. 5, pp. 649-660. R. (2002). Why do neuroprotective drugs that are so promising in animals fail in the clinic? An industry perspective. Clin Exp Pharmacol Physiol, Vol. 29, No. 11, pp. 1030-1034. K. E. (2008). KNS-760704 [(6R)-4,5,6,7-tetrahydro-N6-propyl-2, 6benzothiazole-diamine dihydrochloride monohydrate] for the treatment of amyotrophic lateral sclerosis.

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