By Vincent J. Cristofalo PhD
This quantity offers a transparent, concise evaluation of the present country of data in regards to the biology of getting older √± serving as either a useful graduate-level textual content and a key reference for working towards pros. Over a dozen unusual participants probe the newest advancements in our wisdom of why humans age and the way the method works. those authoritative chapters should not simply written for biologists √± yet for gerontologists in most cases. Marks the 10th anniversary of the once a year overview of Gerontology and Geriatrics.
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Extra resources for Annual Review of Gerontology and Geriatrics, Volume 10, 1990: Biology of Aging
Although the degree of neurological deterioration can be variable, death usually is a result of progressive neurodegeneration during late childhood or early adolescence. , 1977). Growth of cells, as assayed by colony-forming ability following UV irradiation, is much reduced compared to normal. , 1982). No known defect in excision or DNA repair has yet been defined. It has been suggested that UV irradiation produces a chromatin alteration that inhibits replicon initiation (Cleaver, 1982). Three complementation groups have been defined based on RNA synthesis following somatic fusion and UV irradiation, which suggests that heterogeneity is present in the syndrome (Lehmann, 1982).
Progeria: A model disease for the study of accelerated aging. In A. Woodhead, A. D. Blackett, & A. ), Molecular biology of aging (pp. 375-396). New York: Plenum Press. Burger, P. , & Vogel, S. 1973. The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome. American Journal of Pathology, 73, 457-468. GENETIC DISEASES OF PREMATURE AGING 39 Cleaver, J. E. 1982. Normal reconstruction of DNA supercoiling and chromatin structure in Cockayne syndrome cells during repair of damage from ultraviolet light.
M. 1975. Variegated translocation mosaicism in human skin fibroblast cultures. Cytol Cell Genet, 25, 282-298. , Bryand, E. , Rabinovitch, P. , & Martin, G. M. 1980. Effects of chromosome constitution on growth and longevity of human skin fibroblast cultures. American Journal Medical Genetics, 7, 141-154. 40 W. T. , Incefy, G. , & Good, R. A. 1981. Circulating thymic hormone activity in patients and secondary immunodeficiency diseases. American Journal of Medicine, 71, 385394. Jones, K. , Smith, P.